Heart attack

ocor is the market name of Simvastatin, a medication that is used to lower heightened levels of fat (lipid). It is not used alone but with diet, exercise and loss of weight. Taken by mouth, it can also be used to lower the heart problem risks in patients.

Liver problems, heightened sugar levels, and Rhabdomyolysis (muscle breakdown) are the serious side effects. Nausea, headaches and constipation are some of the common side effects.

Although, people who suffer from kidney problems should only consume a small dose. Also, taking it during pregnancy, can harm the unborn, and shouldn’t be consumed by the women who breastfeed.

Developed in 1992 by Merck, it’s listed in the Essential Medicine list of World Health Organization and is available as a general medication.

Medicinal uses

Primarily used to treat dyslipidemia and for preventing heart attack and stroke in patients with high risk. It is also used with a diet consisting of low cholesterol food.

The risks of requiring coronary revascularization, heart attack or stroke were decreased by 37%, 37% and 28% respectively.

In the simplest terms, it reduces the cholesterol created by the liver. It works by increasing good cholesterol and by reducing bad cholesterol and triglycerides.

Blood Pressure

How it should be used?

Usually taken by mouth and the dosage are according to the doctor’s prescription. The tablet is usually taken once daily in the evening.

The liquid form is taken on an empty stomach. Before each dose, the bottle should be shaken for 20 seconds. The dosage should also be measured with a proper device/spoon. Using a household spoon may not get a correct dose.

Dosage are based on age, treatment, medical condition, and any other drugs that we may be taking.

It should be taken regularly for the most benefit. Even if you start feeling well, this medication should be continued as most of the people with triglycerides and high cholesterol do not feel ill.


Consumption of Zocor can lead to severe birth defects in the child, if it is consumed during pregnancy. Its consumption can also lead to an imbalance in the lipid metabolism of the infant.

It can also cause complications when taken by someone who’s pregnant, does breastfeeding and is suffering from a liver disease.


Iovastatin is closely related to the development of simvastatin. At Merck, Jesse Huff, the biochemist, and his colleagues, for researching the biosynthesis of cholesterol.

Carl Hoffman, and Karl Folkers and their colleagues isolated mevalonic acid from a yeast extract in 1956.

Max Planck Institute’s researchers discovered thee HMG-CoA reductase enzyme in 1959. This was the discovery because of which scientists all over the world, were encouraged to find the enzyme’s effective inhibitor.

While working at Daiichi Sankyo, Japan, Akira Endo isolated, mevastatin, the first inhibitor from fungus, Penicillium citrinium, in 1976.

Hoffman and his colleagues extracted Iovastatin from the fungus, Aspergillus terreus, in 1979. Before Merck & co. lost their patent, it was the second-largest-selling cholesterol lowering drug and the highest-selling drug in the world.

Originally, the patent of Zocor was supposed to last till January 2006, but expired on 23 June, 2006. The extension was granted after the data from a study was submitted by Merck to the Patent Trademark Office. The study was done to figure out the drug’s positive effect on children.

The above is for the United States patent, as the United Kingdom patent had expired in 2004.


Simvastatin has been available as a generic drug since 2006, although, it came to light in the 1980s. Since 2006, most statin drugs’ prices have decreased.

Adverse effects

Eczema and indigestion and common side effects. Muscle cramps, joint pain and memory loss are also rare side effects. Serious allergic reactions are rare in simvastatin. Medical attention should be taken immediately in case of: dizziness, hoarseness, swelling/itching, and rashes.


Kidney disease, alcohol use and liver disease are some conditions in which it shouldn’t be consumed.


Some interactions of Zocor, with some drugs and grapefruit juice, are also used in the treatment of cardiovascular disease.

Side effect risks increase by three times when it is taken with grapefruit juice.

Zocor should not be taken by people suffering from erythromycin, ciclosporin, gemfibrozil, telithromycin, parconazole, amlodipine, diltiazem, amiodarone and more.

Red yeast rice shouldn’t be used when it’s taken as some red years rice also contain Iovastatin. Red yeast rice and simvastatin’s consumption together can increase liver and muscle problems’ risk.



Zocor can effectively lower lipid can half low density lipoprotein (LDL). It interacts with PPAR-alpha, a transcription factor that lowers lipid, and it’s been shown that this interaction can help in controlling the drug’s neurotrophic action.


Developed in 1992 by Merck, it’s listed in the Essential Medicine list of World Health Organization and is available as a general medication.

Since the expiry of the patent of Merck & Co, Simvastatin is generally available in most countries, even as a generic medication.

After the patent’s expiration, Teva Pharmaceutical Industries, and Ranbaxy Laboratories started api manufacturing and selling simvastatin after getting the approval from FDA.


If any person who has consumed Simvastatin shows serious symptoms, such as having trouble breathing, or passing out, emergency medical attention is needed.

Missed dose

If you miss the dose that is near to the time of the next dose, forget about the missed dose and skip it, and continue your next dose on the regular time. Dose shouldn’t be doubled to catch up.


They should be kept away from moisture and light in room temperature. It shouldn’t be frozen or refrigerated and not to be stored in the bathroom.


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